About F-box/WD repeat-containing protein 7
F-box/WD repeat-containing protein 7 (FBXW7) is a protein
from Homo sapiens identified by UniProt accession
Q969H0, 707 residues long.
MolForge cross-references it against 0 known binders and
594 disease associations.
Target properties
| Protein name | F-box/WD repeat-containing protein 7 |
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| UniProt accession | Q969H0 |
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| Gene | FBXW7 |
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| Organism | Homo sapiens |
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| Length | 707 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (594)
Diseases linked to this target (Open Targets).
- developmental delay, hypotonia, and impaired language · score 0.71
- colorectal adenocarcinoma · score 0.65
- cervical squamous cell carcinoma · score 0.58
- head and neck squamous cell carcinoma · score 0.55
- gastric adenocarcinoma · score 0.55
- Uterine Carcinosarcoma · score 0.54
- endometrial cancer · score 0.54
- esophageal cancer · score 0.53
- squamous cell lung carcinoma · score 0.53
- urinary bladder cancer · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969H0-F1 | alphafold | PREDICTED | 76.99 | — |
Amino-acid sequence (707 residues)
MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE DEEHAGEQDE EDEEEEEMDQ ESDDFDQSDD SSREDEHTHT NSVTNSSSIV DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD NTLKVWSAVT GKCLRTLVGH TGGVWSSQMR DNIIISGSTD RTLKVWNAET GECIHTLYGH TSTVRCMHLH EKRVVSGSRD ATLRVWDIET GQCLHVLMGH VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH TNRVYSLQFD GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL DFDVDMK
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