About Connector enhancer of kinase suppressor of ras 1
Connector enhancer of kinase suppressor of ras 1 (CNKSR1) is a protein
from Homo sapiens identified by UniProt accession
Q969H4, 720 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Connector enhancer of kinase suppressor of ras 1 |
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| UniProt accession | Q969H4 |
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| Gene | CNKSR1 |
|---|
| Organism | Homo sapiens |
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| Length | 720 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- cancer · score 0.59
- Noonan syndrome · score 0.53
- Costello syndrome · score 0.50
- hypertrophic cardiomyopathy · score 0.50
- cardiofaciocutaneous syndrome · score 0.37
- thyroid gland adenocarcinoma · score 0.30
- glioblastoma multiforme · score 0.29
- lung adenocarcinoma · score 0.29
- breast adenocarcinoma · score 0.29
- endometrial cancer · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969H4-F1 | alphafold | PREDICTED | 67.91 | — |
Amino-acid sequence (720 residues)
MEPVETWTPG KVATWLRGLD DSLQDYPFED WQLPGKNLLQ LCPQSLEALA VRSLGHQELI LGGVEQLQAL SSRLQTENLQ SLTEGLLGAT HDFQSIVQGC LGDCAKTPID VLCAAVELLH EADALLFWLS RYLFSHLNDF SACQEIRDLL EELSQVLHED GPAAEKEGTV LRICSHVAGI CHNILVCCPK ELLEQKAVLE QVQLDSPLGL EIHTTSNCQH FVSQVDTQVP TDSRLQIQPG DEVVQINEQV VVREERDMVG WPRKNMVREL LREPAGLSLV LKKIPIPETP PQTPPQVLDS PHQRSPSLSL APLSPRAPSE DVFAFDLSSN PSPGPSPAWT DSASLGPEPL PIPPEPPAIL PAGVAGTPGL PESPDKSPVG RKKSKGLATR LSRRRVSCRE LGRPDCDGWL LLRKAPGGFM GPRWRRRWFV LKGHTLYWYR QPQDEKAEGL INVSNYSLES GHDQKKKYVF QLTHDVYKPF IFAADTLTDL SMWVRHLITC ISKYQSPGRA PPPREEDCYS ETEAEDPDDE AGSHSASPSP AQAGSPLHGD TSPAATPTQR SPRTSFGSLT DSSEEALEGM VRGLRQGGVS LLGQPQPLTQ EQWRSSFMRR NRDPQLNERV HRVRALQSTL KAKLQELQVL EEVLGDPELT GEKFRQWKEQ NRELYSEGLG AWGVAQAEGS SHILTSDSTE QSPHSLPSDP EEHSHLCPLT SESSLRPPDL
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