About Zinc finger protein with KRAB and SCAN domains 4
Zinc finger protein with KRAB and SCAN domains 4 (ZKSCAN4) is a protein
from Homo sapiens identified by UniProt accession
Q969J2, 545 residues long.
MolForge cross-references it against 0 known binders and
102 disease associations.
Target properties
| Protein name | Zinc finger protein with KRAB and SCAN domains 4 |
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| UniProt accession | Q969J2 |
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| Gene | ZKSCAN4 |
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| Organism | Homo sapiens |
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| Length | 545 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (102)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- base metabolic rate measurement · score 0.19
- schizophrenia · score 0.16
- basophil count · score 0.13
- major depressive disorder · score 0.11
- autism spectrum disorder · score 0.11
- reticulocyte count · score 0.10
- anxiety · score 0.09
- stress-related disorder · score 0.09
- lean body mass · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969J2-F1 | alphafold | PREDICTED | 61.06 | — |
Amino-acid sequence (545 residues)
MAREPRKNAA LDAQSAEDQT GLLTVKVEKE EASALTAEVR APCSPARGPE RSRQRFRGFR YPEAAGPREA LSRLRELCGQ WLQPEMHSKE QILELLVLEQ FLTILPGNLQ SWVREQHPES GEEVVVLLEY LERQLDEPAP QVPVGDQGQE LLCCKMALLT QTQGSQSSQC QPMKALFKHE SLGSQPLHDR VLQVPGLAQG GCCREDAMVA SRLTPGSQGL LKMEDVALTL TPGWTQLDSS QVNLYRDEKQ ENHSSLVSLG GEIQTKSRDL PPVKKLPEKE HGKICHLRED IAQIPTHAEA GEQEGRLQRK QKNAIGSRRH YCHECGKSFA QSSGLTKHRR IHTGEKPYEC EDCGKTFIGS SALVIHQRVH TGEKPYECEE CGKVFSHSSN LIKHQRTHTG EKPYECDDCG KTFSQSCSLL EHHKIHTGEK PYQCNMCGKA FRRNSHLLRH QRIHGDKNVQ NPEHGESWES QGRTESQWEN TEAPVSYKCN ECERSFTRNR SLIEHQKIHT GEKPYQCDTC GKGFTRTSYL VQHQRSHVGK KTLSQ
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