About Interleukin-22 receptor subunit alpha-2
Interleukin-22 receptor subunit alpha-2 (IL22RA2) is a protein
from Homo sapiens identified by UniProt accession
Q969J5, 263 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | Interleukin-22 receptor subunit alpha-2 |
|---|
| UniProt accession | Q969J5 |
|---|
| Gene | IL22RA2 |
|---|
| Organism | Homo sapiens |
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| Length | 263 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (128)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.35
- CINCA syndrome · score 0.18
- Behcet's syndrome · score 0.14
- ulcerative colitis · score 0.11
- vital capacity · score 0.11
- neoplasm · score 0.09
- body mass index · score 0.08
- influenza · score 0.08
- infection · score 0.08
- infect · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969J5-F1 | alphafold | PREDICTED | 78.37 | — |
Amino-acid sequence (263 residues)
MMPKHCFLGF LISFFLTGVA GTQSTHESLK PQRVQFQSRN FHNILQWQPG RALTGNSSVY FVQYKIMFSC SMKSSHQKPS GCWQHISCNF PGCRTLAKYG QRQWKNKEDC WGTQELSCDL TSETSDIQEP YYGRVRAASA GSYSEWSMTP RFTPWWETKI DPPVMNITQV NGSLLVILHA PNLPYRYQKE KNVSIEDYYE LLYRVFIINN SLEKEQKVYE GAHRAVEIEA LTPHSSYCVV AEIYQPMLDR RSQRSEERCV EIP
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