About Ankyrin repeat and BTB/POZ domain-containing protein 1
Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1) is a protein
from Homo sapiens identified by UniProt accession
Q969K4, 478 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Ankyrin repeat and BTB/POZ domain-containing protein 1 |
|---|
| UniProt accession | Q969K4 |
|---|
| Gene | ABTB1 |
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| Organism | Homo sapiens |
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| Length | 478 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (45)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.28
- triglyceride measurement · score 0.27
- Red cell distribution width · score 0.26
- FEV/FVC ratio · score 0.23
- waist-hip ratio · score 0.22
- BMI-adjusted waist-hip ratio · score 0.22
- neurodegenerative disease · score 0.20
- Abnormality of refraction · score 0.19
- refractive error · score 0.19
- protein measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969K4-F1 | alphafold | PREDICTED | 86.49 | — |
Amino-acid sequence (478 residues)
MDTSDLFASC RKGDVGRVRY LLEQRDVEVN VRDKWDSTPL YYACLCGHEE LVLYLLANGA RCEANTFDGE RCLYGALSDP IRRALRDYKQ VTASCRRRDY YDDFLQRLLE QGIHSDVVFV VHGKPFRVHR CVLGARSAYF ANMLDTKWKG KSVVVLRHPL INPVAFGALL QYLYTGRLDI GVEHVSDCER LAKQCQLWDL LSDLEAKCEK VSEFVASKPG TCVKVLTIEP PPADPRLRED MALLADCALP PELRGDLWEL PFPCPDGFNS CPDICFRVAG CSFLCHKAFF CGRSDYFRAL LDDHFRESEE PATSGGPPAV TLHGISPDVF THVLYYMYSD HTELSPEAAY DVLSVADMYL LPGLKRLCGR SLAQMLDEDT VVGVWRVAKL FRLARLEDQC TEYMAKVIEK LVEREDFVEA VKEEAAAVAA RQETDSIPLV DDIRFHVAST VQTYSAIEEA QQRLRALEDL LVSIGLDC
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