About Transmembrane protein 54
Transmembrane protein 54 (TMEM54) is a protein
from Homo sapiens identified by UniProt accession
Q969K7, 222 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Transmembrane protein 54 |
|---|
| UniProt accession | Q969K7 |
|---|
| Gene | TMEM54 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 222 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (38)
Diseases linked to this target (Open Targets).
- body mass index · score 0.11
- fat body mass · score 0.05
- neoplasm · score 0.04
- body fat percentage · score 0.03
- lean body mass · score 0.03
- polycystic ovary syndrome · score 0.03
- hepatocellular carcinoma · score 0.03
- mosaic loss of chromosome Y measurement · score 0.03
- waist circumference · score 0.02
- colorectal cancer · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969K7-F1 | alphafold | PREDICTED | 77.80 | — |
Amino-acid sequence (222 residues)
MCLRLGGLSV GDFRKVLMKT GLVLVVLGHV SFITAALFHG TVLRYVGTPQ DAVALQYCVV NILSVTSAIV VITSGIAAIV LSRYLPSTPL RWTVFSSSVA CALLSLTCAL GLLASIAMTF ATQGKALLAA CTFGSSELLA LAPDCPFDPT RIYSSSLCLW GIALVLCVAE NVFAVRCAQL THQLLELRPW WGKSSHHMMR ENPELVEGRD LLSCTSSEPL TL
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