NEDD8-conjugating enzyme UBE2F (UBE2F)

About NEDD8-conjugating enzyme UBE2F

NEDD8-conjugating enzyme UBE2F (UBE2F) is a protein from Homo sapiens identified by UniProt accession Q969M7, 185 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	NEDD8-conjugating enzyme UBE2F
UniProt accession	Q969M7
Gene	UBE2F
Organism	Homo sapiens
Length	185 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
eosinophil count · score 0.31
non-small cell lung carcinoma · score 0.15
myeloid white cell count · score 0.13
leukocyte count · score 0.12
appendicular lean mass · score 0.11
mathematical ability · score 0.07
sleep measurement · score 0.05
protein measurement · score 0.04
neoplasm · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q969M7-F1	alphafold	PREDICTED	89.20	—

Amino-acid sequence (185 residues)

MLTLASKLKR DDGLKGSRTA ATASDSTRRV SVRDKLLVKE VAELEANLPC TCKVHFPDPN KLHCFQLTVT PDEGYYQGGK FQFETEVPDA YNMVPPKVKC LTKIWHPNIT ETGEICLSLL REHSIDGTGW APTRTLKDVV WGLNSLFTDL LNFDDPLNIE AAEHHLRDKE DFRNKVDDYI KRYAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards