Trace amine-associated receptor 8 (TAAR8)

About Trace amine-associated receptor 8

Trace amine-associated receptor 8 (TAAR8) is a protein from Homo sapiens identified by UniProt accession Q969N4, 342 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Trace amine-associated receptor 8
UniProt accession	Q969N4
Gene	TAAR8
Organism	Homo sapiens
Length	342 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.18
cutaneous melanoma · score 0.17
endometrial cancer · score 0.16
thyroid gland adenocarcinoma · score 0.16
esophageal cancer · score 0.13
squamous cell lung carcinoma · score 0.12
metabolite measurement · score 0.08
ichthyosis-hepatosplenomegaly-cerebellar degeneration syndrome · score 0.03
Familial ocular anterior segment mesenchymal dysgenesis · score 0.03
autosomal dominant limb-girdle muscular dystrophy type 1G · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q969N4-F1	alphafold	PREDICTED	91.21	—

Amino-acid sequence (342 residues)

MTSNFSQPVV QLCYEDVNGS CIETPYSPGS RVILYTAFSF GSLLAVFGNL LVMTSVLHFK QLHSPTNFLI ASLACADFLV GVTVMLFSMV RTVESCWYFG AKFCTLHSCC DVAFCYSSVL HLCFICIDRY IVVTDPLVYA TKFTVSVSGI CISVSWILPL TYSGAVFYTG VNDDGLEELV SALNCVGGCQ IIVSQGWVLI DFLLFFIPTL VMIILYSKIF LIAKQQAIKI ETTSSKVESS SESYKIRVAK RERKAAKTLG VTVLAFVISW LPYTVDILID AFMGFLTPAY IYEICCWSAY YNSAMNPLIY ALFYPWFRKA IKLILSGDVL KASSSTISLF LE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards