About Immunoglobulin superfamily member 8
Immunoglobulin superfamily member 8 (IGSF8) is a protein
from Homo sapiens identified by UniProt accession
Q969P0, 613 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Immunoglobulin superfamily member 8 |
|---|
| UniProt accession | Q969P0 |
|---|
| Gene | IGSF8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 613 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.22
- MODY · score 0.11
- red blood cell density measurement · score 0.09
- type 2 diabetes mellitus · score 0.08
- type 1 diabetes mellitus · score 0.07
- diabetes mellitus, transient neonatal, 2 · score 0.07
- hyperinsulinism due to glucokinase deficiency · score 0.05
- granulocyte count · score 0.03
- infection · score 0.02
- infect · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969P0-F1 | alphafold | PREDICTED | 88.06 | — |
Amino-acid sequence (613 residues)
MGALRPTLLP PSLPLLLLLM LGMGCWAREV LVPEGPLYRV AGTAVSISCN VTGYEGPAQQ NFEWFLYRPE APDTALGIVS TKDTQFSYAV FKSRVVAGEV QVQRLQGDAV VLKIARLQAQ DAGIYECHTP STDTRYLGSY SGKVELRVLP DVLQVSAAPP GPRGRQAPTS PPRMTVHEGQ ELALGCLART STQKHTHLAV SFGRSVPEAP VGRSTLQEVV GIRSDLAVEA GAPYAERLAA GELRLGKEGT DRYRMVVGGA QAGDAGTYHC TAAEWIQDPD GSWAQIAEKR AVLAHVDVQT LSSQLAVTVG PGERRIGPGE PLELLCNVSG ALPPAGRHAA YSVGWEMAPA GAPGPGRLVA QLDTEGVGSL GPGYEGRHIA MEKVASRTYR LRLEAARPGD AGTYRCLAKA YVRGSGTRLR EAASARSRPL PVHVREEGVV LEAVAWLAGG TVYRGETASL LCNISVRGGP PGLRLAASWW VERPEDGELS SVPAQLVGGV GQDGVAELGV RPGGGPVSVE LVGPRSHRLR LHSLGPEDEG VYHCAPSAWV QHADYSWYQA GSARSGPVTV YPYMHALDTL FVPLLVGTGV ALVTGATVLG TITCCFMKRL RKR
Explore Immunoglobulin superfamily member 8 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets