Endonuclease 8-like 2 (NEIL2)

About Endonuclease 8-like 2

Endonuclease 8-like 2 (NEIL2) is a protein from Homo sapiens identified by UniProt accession Q969S2, 332 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.

Target properties

Protein name	Endonuclease 8-like 2
UniProt accession	Q969S2
Gene	NEIL2
Organism	Homo sapiens
Length	332 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (110)

Diseases linked to this target (Open Targets).

triglyceride measurement · score 0.33
alcohol drinking · score 0.30
apolipoprotein A 1 measurement · score 0.29
alcohol consumption measurement · score 0.27
polycystic ovary syndrome · score 0.25
neurodegenerative disease · score 0.23
gut microbiome measurement · score 0.22
Calcium channel blocker use measurement · score 0.21
Cholecystitis · score 0.20
cholelithiasis · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q969S2-F1	alphafold	PREDICTED	81.05	—

Amino-acid sequence (332 residues)

MPEGPLVRKF HHLVSPFVGQ QVVKTGGSSK KLQPASLQSL WLQDTQVHGK KLFLRFDLDE EMGPPGSSPT PEPPQKEVQK EGAADPKQVG EPSGQKTLDG SSRSAELVPQ GEDDSEYLER DAPAGDAGRW LRVSFGLFGS VWVNDFSRAK KANKRGDWRD PSPRLVLHFG GGGFLAFYNC QLSWSSSPVV TPTCDILSEK FHRGQALEAL GQAQPVCYTL LDQRYFSGLG NIIKNEALYR AGIHPLSLGS VLSASRREVL VDHVVEFSTA WLQGKFQGRP QHTQVYQKEQ CPAGHQVMKE AFGPEDGLQR LTWWCPQCQP QLSEEPEQCQ FS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards