About Cytoplasmic 60S subunit biogenesis factor ZNF622
Cytoplasmic 60S subunit biogenesis factor ZNF622 (ZNF622) is a protein
from Homo sapiens identified by UniProt accession
Q969S3, 477 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Cytoplasmic 60S subunit biogenesis factor ZNF622 |
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| UniProt accession | Q969S3 |
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| Gene | ZNF622 |
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| Organism | Homo sapiens |
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| Length | 477 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.14
- adolescent idiopathic scoliosis · score 0.11
- neuritic plaque measurement · score 0.08
- insulin sensitivity measurement · score 0.06
- body mass index · score 0.06
- Obesity · score 0.03
- systemic juvenile idiopathic arthritis · score 0.01
- triple-negative breast cancer · score 0.01
- Hepatic steatosis · score 0.01
- head and neck squamous cell carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969S3-F1 | alphafold | PREDICTED | 72.28 | — |
Amino-acid sequence (477 residues)
MATYTCITCR VAFRDADMQR AHYKTDWHRY NLRRKVASMA PVTAEGFQER VRAQRAVAEE ESKGSATYCT VCSKKFASFN AYENHLKSRR HVELEKKAVQ AVNRKVEMMN EKNLEKGLGV DSVDKDAMNA AIQQAIKAQP SMSPKKAPPA PAKEARNVVA VGTGGRGTHD RDPSEKPPRL QWFEQQAKKL AKQQEEDSEE EEEDLDGDDW EDIDSDEELE CEDTEAMDDV VEQDAEEEEA EEGPPLGAIP ITDCLFCSHH SSSLMKNVAH MTKDHSFFIP DIEYLSDIKG LIKYLGEKVG VGKICLWCNE KGKSFYSTEA VQAHMNDKSH CKLFTDGDAA LEFADFYDFR SSYPDHKEGE DPNKAEELPS EKNLEYDDET MELILPSGAR VGHRSLMRYY KQRFGLSRAV AVAKNRKAVG RVLQQYRALG WTGSTGAALM RERDMQYVQR MKSKWMLKTG MKNNATKQMH FRVQVRF
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