About Transmembrane protein 203
Transmembrane protein 203 (TMEM203) is a protein
from Homo sapiens identified by UniProt accession
Q969S6, 136 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | Transmembrane protein 203 |
|---|
| UniProt accession | Q969S6 |
|---|
| Gene | TMEM203 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 136 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (139)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- reticulocyte count · score 0.09
- azoospermia · score 0.08
- mean corpuscular hemoglobin concentration · score 0.08
- mean corpuscular volume · score 0.07
- erythrocyte count · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- mean corpuscular hemoglobin · score 0.06
- spermatogenic failure 25 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969S6-F1 | alphafold | PREDICTED | 85.09 | — |
Amino-acid sequence (136 residues)
MLFSLRELVQ WLGFATFEIF VHLLALLVFS VLLALRVDGL VPGLSWWNVF VPFFAADGLS TYFTTIVSVR LFQDGEKRLA VLRLFWVLTV LSLKFVFEML LCQKLAEQTR ELWFGLITSP LFILLQLLMI RACRVN
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