About Polyamine deacetylase HDAC10
Polyamine deacetylase HDAC10 (HDAC10) is a protein
from Homo sapiens identified by UniProt accession
Q969S8, 669 residues long.
MolForge cross-references it against 0 known binders and
196 disease associations.
Target properties
| Protein name | Polyamine deacetylase HDAC10 |
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| UniProt accession | Q969S8 |
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| Gene | HDAC10 |
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| Organism | Homo sapiens |
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| Length | 669 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (196)
Diseases linked to this target (Open Targets).
- multiple myeloma · score 0.55
- neoplasm · score 0.54
- unspecified peripheral T-cell lymphoma · score 0.52
- T-cell non-Hodgkin lymphoma · score 0.46
- Cutaneous T-cell lymphoma · score 0.41
- graft versus host disease · score 0.39
- primary myelofibrosis · score 0.38
- lymphoma · score 0.35
- breast adenocarcinoma · score 0.34
- breast cancer · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969S8-F1 | alphafold | PREDICTED | 90.00 | — |
Amino-acid sequence (669 residues)
MGTALVYHED MTATRLLWDD PECEIERPER LTAALDRLRQ RGLEQRCLRL SAREASEEEL GLVHSPEYVS LVRETQVLGK EELQALSGQF DAIYFHPSTF HCARLAAGAG LQLVDAVLTG AVQNGLALVR PPGHHGQRAA ANGFCVFNNV AIAAAHAKQK HGLHRILVVD WDVHHGQGIQ YLFEDDPSVL YFSWHRYEHG RFWPFLRESD ADAVGRGQGL GFTVNLPWNQ VGMGNADYVA AFLHLLLPLA FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRVCAV LEGGYHLESL AESVCMTVQT LLGDPAPPLS GPMAPCQSAL ESIQSARAAQ APHWKSLQQQ DVTAVPMSPS SHSPEGRPPP LLPGGPVCKA AASAPSSLLD QPCLCPAPSV RTAVALTTPD ITLVLPPDVI QQEASALREE TEAWARPHES LAREEALTAL GKLLYLLDGM LDGQVNSGIA ATPASAAAAT LDVAVRRGLS HGAQRLLCVA LGQLDRPPDL AHDGRSLWLN IRGKEAAALS MFHVSTPLPV MTGGFLSCIL GLVLPLAYGF QPDLVLVALG PGHGLQGPHA ALLAAMLRGL AGGRVLALLE ENSTPQLAGI LARVLNGEAP PSLGPSSVAS PEDVQALMYL RGQLEPQWKM LQCHPHLVA
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