About Sorting nexin-21
Sorting nexin-21 (SNX21) is a protein
from Homo sapiens identified by UniProt accession
Q969T3, 373 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Sorting nexin-21 |
|---|
| UniProt accession | Q969T3 |
|---|
| Gene | SNX21 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 373 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (19)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.09
- platelet count · score 0.08
- body height · score 0.05
- vital capacity · score 0.03
- triglyceride measurement · score 0.02
- Alzheimer disease · score 0.01
- laryngeal squamous cell carcinoma · score 0.01
- breast cancer · score 0.01
- glioblastoma multiforme · score 0.00
- adrenal cortex carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969T3-F1 | alphafold | PREDICTED | 75.40 | — |
Amino-acid sequence (373 residues)
MHRGTQEGAM ASRLLHRLRH ALAGDGPGEA AASPEAEQFP ESSELEDDDA EGLSSRLSGT LSFTSAEDDE DDEDEDDEEA GPDQLPLGDG TSGEDAERSP PPDGQWGSQL LARQLQDFWK KSRNTLAPQR LLFEVTSANV VKDPPSKYVL YTLAVIGPGP PDCQPAQISR RYSDFERLHR NLQRQFRGPM AAISFPRKRL RRNFTAETIA RRSRAFEQFL GHLQAVPELR HAPDLQDFFV LPELRRAQSL TCTGLYREAL ALWANAWQLQ AQLGTPSGPD RPLLTLAGLA VCHQELEDPG EARACCEKAL QLLGDKSLHP LLAPFLEAHV RLSWRLGLDK RQSEARLQAL QEAGLTPTPP PSLKELLIKE VLD
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