About F-box/WD repeat-containing protein 5
F-box/WD repeat-containing protein 5 (FBXW5) is a protein
from Homo sapiens identified by UniProt accession
Q969U6, 566 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | F-box/WD repeat-containing protein 5 |
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| UniProt accession | Q969U6 |
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| Gene | FBXW5 |
|---|
| Organism | Homo sapiens |
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| Length | 566 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (45)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.40
- lung adenocarcinoma · score 0.25
- endometrial cancer · score 0.25
- head and neck squamous cell carcinoma · score 0.25
- gastric adenocarcinoma · score 0.25
- breast adenocarcinoma · score 0.25
- urinary bladder cancer · score 0.24
- clear cell renal carcinoma · score 0.18
- squamous cell lung carcinoma · score 0.18
- blood protein measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969U6-F1 | alphafold | PREDICTED | 84.00 | — |
Amino-acid sequence (566 residues)
MDEGGTPLLP DSLVYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWREQF YRYYQVARDV PRHPAAMSWY EEFQRLYDTV PCVEVQTLRE HTDQVLHLSF SHSGYQFASC SKDCTVKIWS NDLTISLLHS ADMRPYNWSY TQFSQFNKDD SLLLASGVFL GPHNSSSGEI AVISLDSFAL LSRVRNKPYD VFGCWLTETS LISGNLHRIG DITSCSVLWL NNAFQDVESE NVNVVKRLFK IQNLNASTVR TVMVADCSRF DSPDLLLEAG DPATSPCRIF DLGSDNEEVV AGPAPAHAKE GLRHFLDRVL EGRAQPQLSE RMLETKVAEL LAQGHTKPPE RSATGAKSKY LIFTTGCLTY SPHQIGIKQI LPHQMTTAGP VLGEGRGSDA FFDALDHVID IHGHIIGMGL SPDNRYLYVN SRAWPNGAVV ADPMQPPPIA EEIDLLVFDL KTMREVRRAL RAHRAYTPND ECFFIFLDVS RDFVASGAED RHGYIWDRHY NICLARLRHE DVVNSVVFSP QEQELLLTAS DDATIKAWRS PRTMRVLQAP RPRPRTFFSW LASQRR
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