Melanin-concentrating hormone receptor 2 (MCHR2)

About Melanin-concentrating hormone receptor 2

Melanin-concentrating hormone receptor 2 (MCHR2) is a protein from Homo sapiens identified by UniProt accession Q969V1, 340 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.

Target properties

Protein name	Melanin-concentrating hormone receptor 2
UniProt accession	Q969V1
Gene	MCHR2
Organism	Homo sapiens
Length	340 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (81)

Diseases linked to this target (Open Targets).

alcohol consumption measurement · score 0.33
smoking status measurement · score 0.33
low density lipoprotein cholesterol measurement · score 0.32
neurodegenerative disease · score 0.32
BMI-adjusted waist-hip ratio · score 0.30
lean body mass · score 0.30
total cholesterol measurement · score 0.29
waist-hip ratio · score 0.29
body weight · score 0.28
apolipoprotein B measurement · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q969V1-F1	alphafold	PREDICTED	88.85	—

Amino-acid sequence (340 residues)

MNPFHASCWN TSAELLNKSW NKEFAYQTAS VVDTVILPSM IGIICSTGLV GNILIVFTII RSRKKTVPDI YICNLAVADL VHIVGMPFLI HQWARGGEWV FGGPLCTIIT SLDTCNQFAC SAIMTVMSVD RYFALVQPFR LTRWRTRYKT IRINLGLWAA SFILALPVWV YSKVIKFKDG VESCAFDLTS PDDVLWYTLY LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS VPKQRVMKLT KMVLVLVVVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS INPFLYILLS GNFQKRLPQI QRRATEKEIN NMGNTLKSHF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards