BOS complex subunit NCLN (NCLN)

About BOS complex subunit NCLN

BOS complex subunit NCLN (NCLN) is a protein from Homo sapiens identified by UniProt accession Q969V3, 563 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	BOS complex subunit NCLN
UniProt accession	Q969V3
Gene	NCLN
Organism	Homo sapiens
Length	563 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.27
Hirschsprung disease · score 0.26
basophil percentage of leukocytes · score 0.25
neutrophil percentage of leukocytes · score 0.24
leukocyte count · score 0.23
monocyte count · score 0.21
myeloid white cell count · score 0.20
mean corpuscular hemoglobin · score 0.14
eosinophil count · score 0.13
lymphocyte percentage of leukocytes · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q969V3-F1	alphafold	PREDICTED	85.40	—

Amino-acid sequence (563 residues)

MLEEAGEVLE NMLKASCLPL GFIVFLPAVL LLVAPPLPAA DAAHEFTVYR MQQYDLQGQP YGTRNAVLNT EARTMAAEVL SRRCVLMRLL DFSYEQYQKA LRQSAGAVVI ILPRAMAAVP QDVVRQFMEI EPEMLAMETA VPVYFAVEDE ALLSIYKQTQ AASASQGSAS AAEVLLRTAT ANGFQMVTSG VQSKAVSDWL IASVEGRLTG LGGEDLPTIV IVAHYDAFGV APWLSLGADS NGSGVSVLLE LARLFSRLYT YKRTHAAYNL LFFASGGGKF NYQGTKRWLE DNLDHTDSSL LQDNVAFVLC LDTVGRGSSL HLHVSKPPRE GTLQHAFLRE LETVAAHQFP EVRFSMVHKR INLAEDVLAW EHERFAIRRL PAFTLSHLES HRDGQRSSIM DVRSRVDSKT LTRNTRIIAE ALTRVIYNLT EKGTPPDMPV FTEQMQIQQE QLDSVMDWLT NQPRAAQLVD KDSTFLSTLE HHLSRYLKDV KQHHVKADKR DPEFVFYDQL KQVMNAYRVK PAVFDLLLAV GIAAYLGMAY VAVQHFSLLY KTVQRLLVKA KTQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards