Tektin-1 (TEKT1)

About Tektin-1

Tektin-1 (TEKT1) is a protein from Homo sapiens identified by UniProt accession Q969V4, 418 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Tektin-1
UniProt accession	Q969V4
Gene	TEKT1
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

influenza A (H1N1) · score 0.24
late-onset Alzheimers disease · score 0.14
blood metabolite measurement · score 0.08
neutrophil count · score 0.06
Hepatic veno-occlusive disease - immunodeficiency · score 0.04
immunodeficiency 75 · score 0.03
autoinflammation with episodic fever and lymphadenopathy · score 0.03
proteasome-associated autoinflammatory syndrome 4 · score 0.03
central nervous system cancer · score 0.03
ependymoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q969V4-F1	alphafold	PREDICTED	92.86	—

Amino-acid sequence (418 residues)

MAKLLQPPPK FLPSEWHIAN KNQYHRADAQ RSRSERLVAE SQRLVDEIEK TTRKSQSDVN KKLEQRLEEV QFWKKELDDK LEQLVNVTDD LLIYKIRLEK ALETLKEPLH ITETCLAYRE KRIGIDLVHD TVEHELIKEA EIIQGIMALL TRTLEEASEQ IRMNRSAKYN LEKDLKDKFV ALTIDDICFS LNNNSPNIRY SENAVRIEPN SVSLEDWLDF SSTNVEKADK QRNNSLMLKA LVDRILSQTA NDLRKQCDVV DTAFKNGLKD TKDARDKLAD HLAKVMEEIA SQEKNITALE KAILDQEGPA KVAHTRLETR THRPNVELCR DVAQYRLMKE VQEITHNVAR LKETLAQAQA ELKGLHRRQL ALQEEIQVKE NTIYIDEVLC MQMRKSIPLR DGEDHGVWAG GLRPDAVC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards