Serine palmitoyltransferase small subunit A (SPTSSA)

About Serine palmitoyltransferase small subunit A

Serine palmitoyltransferase small subunit A (SPTSSA) is a protein from Homo sapiens identified by UniProt accession Q969W0, 71 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Serine palmitoyltransferase small subunit A
UniProt accession	Q969W0
Gene	SPTSSA
Organism	Homo sapiens
Length	71 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

spastic paraplegia 90A, autosomal dominant · score 0.47
spastic paraplegia 90B, autosomal recessive · score 0.45
neurodegenerative disease · score 0.25
erythrocyte count · score 0.08
hemoglobin measurement · score 0.07
hematocrit · score 0.06
red blood cell density measurement · score 0.05
brain measurement · score 0.05
MODY · score 0.04
hyperinsulinism due to INSR deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q969W0-F1	alphafold	PREDICTED	93.57	—

Amino-acid sequence (71 residues)

MAGMALARAW KQMSWFYYQY LLVTALYMLE PWERTVFNSM LVSIVGMALY TGYVFMPQHI MAILHYFEIV Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards