About Protein lifeguard 3
Protein lifeguard 3 (TMBIM1) is a protein
from Homo sapiens identified by UniProt accession
Q969X1, 311 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Protein lifeguard 3 |
|---|
| UniProt accession | Q969X1 |
|---|
| Gene | TMBIM1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 311 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.35
- myeloid white cell count · score 0.34
- Red cell distribution width · score 0.34
- leukocyte count · score 0.33
- sum of basophil and neutrophil counts · score 0.32
- sum of neutrophil and eosinophil counts · score 0.32
- granulocyte count · score 0.32
- reticulocyte count · score 0.30
- basophil count · score 0.30
- alkaline phosphatase measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969X1-F1 | alphafold | PREDICTED | 76.82 | — |
Amino-acid sequence (311 residues)
MSNPSAPPPY EDRNPLYPGP PPPGGYGQPS VLPGGYPAYP GYPQPGYGHP AGYPQPMPPT HPMPMNYGPG HGYDGEERAV SDSFGPGEWD DRKVRHTFIR KVYSIISVQL LITVAIIAIF TFVEPVSAFV RRNVAVYYVS YAVFVVTYLI LACCQGPRRR FPWNIILLTL FTFAMGFMTG TISSMYQTKA VIIAMIITAV VSISVTIFCF QTKVDFTSCT GLFCVLGIVL LVTGIVTSIV LYFQYVYWLH MLYAALGAIC FTLFLAYDTQ LVLGNRKHTI SPEDYITGAL QIYTDIIYIF TFVLQLMGDR N
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