About FAST kinase domain-containing protein 4
FAST kinase domain-containing protein 4 (TBRG4) is a protein
from Homo sapiens identified by UniProt accession
Q969Z0, 631 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | FAST kinase domain-containing protein 4 |
|---|
| UniProt accession | Q969Z0 |
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| Gene | TBRG4 |
|---|
| Organism | Homo sapiens |
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| Length | 631 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- smoking status measurement · score 0.20
- mitochondrial DNA measurement · score 0.20
- colorectal cancer · score 0.19
- colorectal adenoma · score 0.17
- platelet count · score 0.13
- eosinophil count · score 0.11
- platelet crit · score 0.11
- type 2 diabetes mellitus · score 0.08
- hepatocellular carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q969Z0-F1 | alphafold | PREDICTED | 82.75 | — |
Amino-acid sequence (631 residues)
MAAHLVKRCT CLLREAARQA PAMAPVGRLR LAWVAHKTLT SSATSPISHL PGSLMEPVEK ERASTPYIEK QVDHLIKKAT RPEELLELLG GSHDLDSNQA AMVLIRLSHL LSEKPEDKGL LIQDAHFHQL LCLLNSQIAS VWHGTLSKLL GSLYALGIPK ASKELQSVEQ EVRWRMRKLK YKHLAFLAES CATLSQEQHS QELLAELLTH LERRWTEIED SHTLVTVMMK VGHLSEPLMN RLEDKCLELV EHFGPNELRK VLVMLAAQSR RSVPLLRAIS YHLVQKPFSL TKDVLLDVAY AYGKLSFHQT QVSQRLATDL LSLMPSLTSG EVAHCAKSFA LLKWLSLPLF EAFAQHVLNR AQDITLPHLC SVLLAFARLN FHPDQEDQFF SLVHEKLGSE LPGLEPALQV DLVWALCVLQ QAREAELQAV LHPEFHIQFL GGKSQKDQNT FQKLLHINAT ALLEYPEYSG PLLPASAVAP GPSALDRKVT PLQKELQETL KGLLGSADKG SLEVATQYGW VLDAEVLLDS DGEFLPVRDF VAPHLAQPTG SQSPPPGSKR LAFLRWEFPN FNSRSKDLLG RFVLARRHIV AAGFLIVDVP FYEWLELKSE WQKGAYLKDK MRKAVAEELA K
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