About V-type proton ATPase subunit E 2
V-type proton ATPase subunit E 2 (ATP6V1E2) is a protein
from Homo sapiens identified by UniProt accession
Q96A05, 226 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | V-type proton ATPase subunit E 2 |
|---|
| UniProt accession | Q96A05 |
|---|
| Gene | ATP6V1E2 |
|---|
| Organism | Homo sapiens |
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| Length | 226 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (25)
Diseases linked to this target (Open Targets).
- Abnormality of refraction · score 0.24
- lean body mass · score 0.19
- sitting height measurement · score 0.18
- fat body mass · score 0.15
- lymphocyte count · score 0.13
- excessive daytime sleepiness measurement · score 0.12
- serum alanine aminotransferase measurement · score 0.09
- whole body water mass · score 0.08
- base metabolic rate measurement · score 0.07
- brain measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96A05-F1 | alphafold | PREDICTED | 92.97 | — |
Amino-acid sequence (226 residues)
MALSDVDVKK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR LKIMEYYEKK EKQIEQQKKI LMSTMRNQAR LKVLRARNDL ISDLLSEAKL RLSRIVEDPE VYQGLLDKLV LQGLLRLLEP VMIVRCRPQD LLLVEAAVQK AIPEYMTISQ KHVEVQIDKE AYLAVNAAGG VEVYSGNQRI KVSNTLESRL DLSAKQKMPE IRMALFGANT NRKFFI
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