Histone H2B type 1-A (H2BC1)

About Histone H2B type 1-A

Histone H2B type 1-A (H2BC1) is a protein from Homo sapiens identified by UniProt accession Q96A08, 127 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Histone H2B type 1-A
UniProt accession	Q96A08
Gene	H2BC1
Organism	Homo sapiens
Length	127 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

infectious disease · score 0.50
viral disease · score 0.50
breast carcinoma · score 0.37
melanoma · score 0.37
cancer · score 0.37
diabetes mellitus · score 0.19
waist-hip ratio · score 0.18
diabetic maculopathy · score 0.17
diabetic retinopathy · score 0.13
complication · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96A08-F1	alphafold	PREDICTED	84.88	—

Amino-acid sequence (127 residues)

MPEVSSKGAT ISKKGFKKAV VKTQKKEGKK RKRTRKESYS IYIYKVLKQV HPDTGISSKA MSIMNSFVTD IFERIASEAS RLAHYSKRST ISSREIQTAV RLLLPGELAK HAVSEGTKAV TKYTSSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards