About Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 (RFT1) is a protein
from Homo sapiens identified by UniProt accession
Q96AA3, 541 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 |
|---|
| UniProt accession | Q96AA3 |
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| Gene | RFT1 |
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| Organism | Homo sapiens |
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| Length | 541 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (110)
Diseases linked to this target (Open Targets).
- RFT1-congenital disorder of glycosylation · score 0.81
- congenital disorder of glycosylation · score 0.55
- congenital disorder of glycosylation type I · score 0.37
- sex hormone-binding globulin measurement · score 0.28
- neurodegenerative disease · score 0.28
- body height · score 0.28
- heel bone mineral density · score 0.21
- mean platelet volume · score 0.20
- BMI-adjusted hip circumference · score 0.19
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AA3-F1 | alphafold | PREDICTED | 90.36 | — |
Amino-acid sequence (541 residues)
MGSQEVLGHA ARLASSGLLL QVLFRLITFV LNAFILRFLS KEIVGVVNVR LTLLYSTTLF LAREAFRRAC LSGGTQRDWS QTLNLLWLTV PLGVFWSLFL GWIWLQLLEV PDPNVVPHYA TGVVLFGLSA VVELLGEPFW VLAQAHMFVK LKVIAESLSV ILKSVLTAFL VLWLPHWGLY IFSLAQLFYT TVLVLCYVIY FTKLLGSPES TKLQTLPVSR ITDLLPNITR NGAFINWKEA KLTWSFFKQS FLKQILTEGE RYVMTFLNVL NFGDQGVYDI VNNLGSLVAR LIFQPIEESF YIFFAKVLER GKDATLQKQE DVAVAAAVLE SLLKLALLAG LTITVFGFAY SQLALDIYGG TMLSSGSGPV LLRSYCLYVL LLAINGVTEC FTFAAMSKEE VDRYNFVMLA LSSSFLVLSY LLTRWCGSVG FILANCFNMG IRITQSLCFI HRYYRRSPHR PLAGLHLSPV LLGTFALSGG VTAVSEVFLC CEQGWPARLA HIAVGAFCLG ATLGTAFLTE TKLIHFLRTQ LGVPRRTDKM T
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