About Janus kinase and microtubule-interacting protein 2
Janus kinase and microtubule-interacting protein 2 (JAKMIP2) is a protein
from Homo sapiens identified by UniProt accession
Q96AA8, 810 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Janus kinase and microtubule-interacting protein 2 |
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| UniProt accession | Q96AA8 |
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| Gene | JAKMIP2 |
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| Organism | Homo sapiens |
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| Length | 810 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.38
- glaucoma · score 0.28
- alcoholic pancreatitis · score 0.22
- neoplasm · score 0.05
- Graves disease · score 0.04
- blood protein measurement · score 0.02
- breast carcinoma · score 0.02
- Ataxia-telangiectasia · score 0.01
- lung disease · score 0.01
- rosacea · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AA8-F1 | alphafold | PREDICTED | 79.27 | — |
Amino-acid sequence (810 residues)
MSKKGRNKGE KPEALIVALQ AANEDLRTKL TDIQIELHQE KSKVSKLERE KTQEAKRIRE LEQRKHTVLV TELKAKLHEE KMKELQAVRE NLIKQHEQEM SRTVKVRDGE IQRLKSALCA LRDGSSDKVR TALTIEAREE ARKLFDTERL KLLQEIADLK TAKKQVDEAL SNMIQADKIK AGDLRSEHQS HQEAISKIKW ESERDIRRLM DEIKAKDRII FSLEKELETQ TGYVQKLQLQ KEALDEQLFL VKEAECNMSS PKREIPGRAG DGSEHCSSPD LRRNQKRIAE LNATIRKLED RNTLLGDERN ELLKRVRETE KQCKPLLERN KCLAKRNDEL MVSLQRMEEK LKAVTKENSE MREKITSHPP LKKLKSLNDL DQANEEQETE FLKLQVIEQQ NIIDELTRDR EKLIRRRKHR RSSKPIKRPV LDPFIGYDED SMDSETSSMA SFRTDRTPAT PDDDLDESLA AEESELRFRQ LTKEYQALQR AYALLQEQTG GIIDAEREAK AQEQLQAEVL RYKAKIEDLE ATLAQKGQDS HWVEDKQLFI KRNQELLEKI EKQEAENHRL QQELQDARDQ NELLEFRNLE LEERERRSPP FNLQIHPFSD GVSALQIYCM KEGVKDVNIP DLIKQLDILG DNGNLRNEEQ VAIIQASTVL SLAEKWIQQI EGAEAALHQK MMELESDMEQ FCKIKGYLEE ELDYRKQALD QAYMRIQELE ATLYNALQQE TVIKFGELLS EKQQEELRTA VEKLRRQMLR KSREYDCQIL QERMELLQQA HQRIRDLEDK TDIQKRQIKD LEEKSNRKHG
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