About Isochorismatase domain-containing protein 2
Isochorismatase domain-containing protein 2 (ISOC2) is a protein
from Homo sapiens identified by UniProt accession
Q96AB3, 205 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | Isochorismatase domain-containing protein 2 |
|---|
| UniProt accession | Q96AB3 |
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| Gene | ISOC2 |
|---|
| Organism | Homo sapiens |
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| Length | 205 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (12)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- multiple sclerosis · score 0.22
- lysosomal storage disease · score 0.22
- Alzheimer disease · score 0.22
- Parkinson disease · score 0.22
- vertebral joint disease · score 0.04
- neoplasm · score 0.00
- secondary progressive multiple sclerosis · score 0.00
- chronic kidney disease · score 0.00
- meningeal tuberculosis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AB3-F1 | alphafold | PREDICTED | 95.00 | — |
Amino-acid sequence (205 residues)
MAAARPSLGR VLPGSSVLFL CDMQEKFRHN IAYFPQIVSV AARMLKVARL LEVPVMLTEQ YPQGLGPTVP ELGTEGLRPL AKTCFSMVPA LQQELDSRPQ LRSVLLCGIE AQACILNTTL DLLDRGLQVH VVVDACSSRS QVDRLVALAR MRQSGAFLST SEGLILQLVG DAVHPQFKEI QKLIKEPAPD SGLLGLFQGQ NSLLH
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