About Fermitin family homolog 2
Fermitin family homolog 2 (FERMT2) is a protein
from Homo sapiens identified by UniProt accession
Q96AC1, 680 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Fermitin family homolog 2 |
|---|
| UniProt accession | Q96AC1 |
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| Gene | FERMT2 |
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| Organism | Homo sapiens |
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| Length | 680 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (174)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.49
- intraocular pressure measurement · score 0.48
- systolic blood pressure · score 0.47
- neurodegenerative disease · score 0.45
- PR interval · score 0.41
- diastolic blood pressure · score 0.40
- open-angle glaucoma · score 0.40
- primary angle closure glaucoma · score 0.39
- pulse pressure measurement · score 0.33
- Alzheimer disease · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AC1-F1 | alphafold | PREDICTED | 79.87 | — |
Amino-acid sequence (680 residues)
MALDGIRMPD GCYADGTWEL SVHVTDLNRD VTLRVTGEVH IGGVMLKLVE KLDVKKDWSD HALWWEKKRT WLLKTHWTLD KYGIQADAKL QFTPQHKLLR LQLPNMKYVK VKVNFSDRVF KAVSDICKTF NIRHPEELSL LKKPRDPTKK KKKKLDDQSE DEALELEGPL ITPGSGSIYS SPGLYSKTMT PTYDAHDGSP LSPTSAWFGD SALSEGNPGI LAVSQPITSP EILAKMFKPQ ALLDKAKINQ GWLDSSRSLM EQDVKENEAL LLRFKYYSFF DLNPKYDAIR INQLYEQAKW AILLEEIECT EEEMMMFAAL QYHINKLSIM TSENHLNNSD KEVDEVDAAL SDLEITLEGG KTSTILGDIT SIPELADYIK VFKPKKLTLK GYKQYWCTFK DTSISCYKSK EESSGTPAHQ MNLRGCEVTP DVNISGQKFN IKLLIPVAEG MNEIWLRCDN EKQYAHWMAA CRLASKGKTM ADSSYNLEVQ NILSFLKMQH LNPDPQLIPE QITTDITPEC LVSPRYLKKY KNKQITARIL EAHQNVAQMS LIEAKMRFIQ AWQSLPEFGI THFIARFQGG KKEELIGIAY NRLIRMDAST GDAIKTWRFS NMKQWNVNWE IKMVTVEFAD EVRLSFICTE VDCKVVHEFI GGYIFLSTRA KDQNESLDEE MFYKLTSGWV
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