About Patatin-like phospholipase domain-containing protein 2
Patatin-like phospholipase domain-containing protein 2 (PNPLA2) is a protein
from Homo sapiens identified by UniProt accession
Q96AD5, 504 residues long.
MolForge cross-references it against 0 known binders and
276 disease associations.
Target properties
| Protein name | Patatin-like phospholipase domain-containing protein 2 |
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| UniProt accession | Q96AD5 |
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| Gene | PNPLA2 |
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| Organism | Homo sapiens |
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| Length | 504 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (276)
Diseases linked to this target (Open Targets).
- neutral lipid storage myopathy · score 0.78
- genetic disorder · score 0.45
- Abnormality of the musculature · score 0.33
- BMI-adjusted waist-hip ratio · score 0.28
- high density lipoprotein cholesterol measurement · score 0.22
- BMI-adjusted waist circumference · score 0.19
- Dilated cardiomyopathy · score 0.19
- glioblastoma multiforme · score 0.19
- dilated cardiomyopathy · score 0.18
- HbA1c measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AD5-F1 | alphafold | PREDICTED | 72.49 | — |
Amino-acid sequence (504 residues)
MFPREKTWNI SFAGCGFLGV YYVGVASCLR EHAPFLVANA THIYGASAGA LTATALVTGV CLGEAGAKFI EVSKEARKRF LGPLHPSFNL VKIIRSFLLK VLPADSHEHA SGRLGISLTR VSDGENVIIS HFNSKDELIQ ANVCSGFIPV YCGLIPPSLQ GVRYVDGGIS DNLPLYELKN TITVSPFSGE SDICPQDSST NIHELRVTNT SIQFNLRNLY RLSKALFPPE PLVLREMCKQ GYRDGLRFLQ RNGLLNRPNP LLALPPARPH GPEDKDQAVE SAQAEDYSQL PGEDHILEHL PARLNEALLE ACVEPTDLLT TLSNMLPVRL ATAMMVPYTL PLESALSFTI RLLEWLPDVP EDIRWMKEQT GSICQYLVMR AKRKLGRHLP SRLPEQVELR RVQSLPSVPL SCAAYREALP GWMRNNLSLG DALAKWEECQ RQLLLGLFCT NVAFPPEALR MRAPADPAPA PADPASPQHQ LAGPAPLLST PAPEARPVIG ALGL
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