About Tetratricopeptide repeat protein 17
Tetratricopeptide repeat protein 17 (TTC17) is a protein
from Homo sapiens identified by UniProt accession
Q96AE7, 1141 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 17 |
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| UniProt accession | Q96AE7 |
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| Gene | TTC17 |
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| Organism | Homo sapiens |
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| Length | 1141 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (67)
Diseases linked to this target (Open Targets).
- fibrinogen measurement · score 0.37
- neutrophil count · score 0.26
- body mass index · score 0.25
- migraine disorder · score 0.16
- monocyte percentage of leukocytes · score 0.15
- neutrophil percentage of leukocytes · score 0.13
- mathematical ability · score 0.11
- self reported educational attainment · score 0.11
- PHF-tau measurement · score 0.10
- refractive error · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AE7-F1 | alphafold | PREDICTED | 70.96 | — |
Amino-acid sequence (1141 residues)
MAAAVGVRGR YELPPCSGPG WLLSLSALLS VAARGAFATT HWVVTEDGKI QQQVDSPMNL KHPHDLVILM RQEATVNYLK ELEKQLVAQK IHIEENEDRD TGLEQRHNKE DPDCIKAKVP LGDLDLYDGT YITLESKDIS PEDYIDTESP VPPDPEQPDC TKILELPYSI HAFQHLRGVQ ERVNLSAPLL PKEDPIFTYL SKRLGRSIDD IGHLIHEGLQ KNTSSWVLYN MASFYWRIKN EPYQVVECAM RALHFSSRHN KDIALVNLAN VLHRAHFSAD AAVVVHAALD DSDFFTSYYT LGNIYAMLGE YNHSVLCYDH ALQARPGFEQ AIKRKHAVLC QQKLEQKLEA QHRSLQRTLN ELKEYQKQHD HYLRQQEILE KHKLIQEEQI LRNIIHETQM AKEAQLGNHQ ICRLVNQQHS LHCQWDQPVR YHRGDIFENV DYVQFGEDSS TSSMMSVNFD VQSNQSDIND SVKSSPVAHS ILWIWGRDSD AYRDKQHILW PKRADCTESY PRVPVGGELP TYFLPPENKG LRIHELSSDD YSTEEEAQTP DCSITDFRKS HTLSYLVKEL EVRMDLKAKM PDDHARKILL SRINNYTIPE EEIGSFLFHA INKPNAPIWL ILNEAGLYWR AVGNSTFAIA CLQRALNLAP LQYQDVPLVN LANLLIHYGL HLDATKLLLQ ALAINSSEPL TFLSLGNAYL ALKNISGALE AFRQALKLTT KCPECENSLK LIRCMQFYPF LYNITSSVCS GTVVEESNGS DEMENSDETK MSEEILALVD EFQQAWPLEG FGGALEMKGR RLDLQGIRVL KKGPQDGVAR SSCYGDCRSE DDEATEWITF QVKRVKKPKG DHKKTPGKKV ETGQIENGHR YQANLEITGP KVASPGPQGK KRDYQRLGWP SPDECLKLRW VELTAIVSTW LAVSSKNIDI TEHIDFATPI QQPAMEPLCN GNLPTSMHTL DHLHGVSNRA SLHYTGESQL TEVLQNLGKD QYPQQSLEQI GTRIAKVLEK NQTSWVLSSM AALYWRVKGQ GKKAIDCLRQ ALHYAPHQMK DVPLISLANI LHNAKLWNDA VIVATMAVEI APHFAVNHFT LGNVYVAMEE FEKALVWYES TLKLQPEFVP AKNRIQTIQC HLMLKKGRRS P
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