About Mitochondrial outer membrane protein SLC25A46
Mitochondrial outer membrane protein SLC25A46 (SLC25A46) is a protein
from Homo sapiens identified by UniProt accession
Q96AG3, 418 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Mitochondrial outer membrane protein SLC25A46 |
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| UniProt accession | Q96AG3 |
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| Gene | SLC25A46 |
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| Organism | Homo sapiens |
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| Length | 418 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (82)
Diseases linked to this target (Open Targets).
- neuropathy, hereditary motor and sensory, type vib · score 0.81
- neuropathy, hereditary motor and sensory, type 6B · score 0.76
- pontocerebellar hypoplasia, type 1E · score 0.74
- genetic disorder · score 0.50
- cerebellar ataxia · score 0.46
- Optic atrophy · score 0.37
- optic atrophy · score 0.37
- pontocerebellar hypoplasia type 1 · score 0.37
- hereditary motor and sensory neuropathy type 6 · score 0.37
- asthma · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AG3-F1 | alphafold | PREDICTED | 73.96 | — |
Amino-acid sequence (418 residues)
MHPRRPDGFD GLGYRGGARD EQGFGGAFPA RSFSTGSDLG HWVTTPPDIP GSRNLHWGEK SPPYGVPTTS TPYEGPTEEP FSSGGGGSVQ GQSSEQLNRF AGFGIGLASL FTENVLAHPC IVLRRQCQVN YHAQHYHLTP FTVINIMYSF NKTQGPRALW KGMGSTFIVQ GVTLGAEGII SEFTPLPREV LHKWSPKQIG EHLLLKSLTY VVAMPFYSAS LIETVQSEII RDNTGILECV KEGIGRVIGM GVPHSKRLLP LLSLIFPTVL HGVLHYIISS VIQKFVLLIL KRKTYNSHLA ESTSPVQSML DAYFPELIAN FAASLCSDVI LYPLETVLHR LHIQGTRTII DNTDLGYEVL PINTQYEGMR DCINTIRQEE GVFGFYKGFG AVIIQYTLHA AVLQITKIIY STLLQNNI
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