Adrenocortical dysplasia protein homolog (ACD)

About Adrenocortical dysplasia protein homolog

Adrenocortical dysplasia protein homolog (ACD) is a protein from Homo sapiens identified by UniProt accession Q96AP0, 458 residues long. MolForge cross-references it against 0 known binders and 125 disease associations.

Target properties

Protein name	Adrenocortical dysplasia protein homolog
UniProt accession	Q96AP0
Gene	ACD
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (125)

Diseases linked to this target (Open Targets).

Hoyeraal-Hreidarsson syndrome · score 0.72
dyskeratosis congenita · score 0.68
neurodegenerative disease · score 0.52
hereditary isolated aplastic anemia · score 0.37
breast adenocarcinoma · score 0.27
head and neck squamous cell carcinoma · score 0.26
endometrial cancer · score 0.24
ovarian cancer · score 0.23
squamous cell lung carcinoma · score 0.21
gastric adenocarcinoma · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96AP0-F1	alphafold	PREDICTED	62.36	—

Amino-acid sequence (458 residues)

MAGSGRLVLR PWIRELILGS ETPSSPRAGQ LLEVLQDAEA AVAGPSHAPD TSDVGATLLV SDGTHSVRCL VTREALDTSD WEEKEFGFRG TEGRLLLLQD CGVHVQVAEG GAPAEFYLQV DRFSLLPTEQ PRLRVPGCNQ DLDVQKKLYD CLEEHLSEST SSNAGLSLSQ LLDEMREDQE HQGALVCLAE SCLTLEGPCT APPVTHWAAS RCKATGEAVY TVPSSMLCIS ENDQLILSSL GPCQRTQGPE LPPPDPALQD LSLTLIASPP SSPSSSGTPA LPGHMSSEES GTSISLLPAL SLAAPDPGQR SSSQPSPAIC SAPATLTPRS PHASRTPSSP LQSCTPSLSP RSHVPSPHQA LVTRPQKPSL EFKEFVGLPC KNRPPFPRTG ATRGAQEPCS VWEPPKRHRD GSAFQYEYEP PCTSLCARVQ AVRLPPQLMA WALHFLMDAQ PGSEPTPM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards