About Zinc finger-containing ubiquitin peptidase 1
Zinc finger-containing ubiquitin peptidase 1 (ZUP1) is a protein
from Homo sapiens identified by UniProt accession
Q96AP4, 578 residues long.
MolForge cross-references it against 0 known binders and
180 disease associations.
Target properties
| Protein name | Zinc finger-containing ubiquitin peptidase 1 |
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| UniProt accession | Q96AP4 |
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| Gene | ZUP1 |
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| Organism | Homo sapiens |
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| Length | 578 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (180)
Diseases linked to this target (Open Targets).
- cancer · score 0.08
- colorectal carcinoma · score 0.08
- colitis · score 0.07
- hepatocellular carcinoma · score 0.06
- head and neck squamous cell carcinoma · score 0.05
- sitting height measurement · score 0.05
- neoplasm · score 0.05
- non-small cell lung carcinoma · score 0.04
- triple-negative breast cancer · score 0.04
- infection · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AP4-F1 | alphafold | PREDICTED | 79.82 | — |
Amino-acid sequence (578 residues)
MLSCNICGET VTSEPDMKAH LIVHMESEII CPFCKLSGVN YDEMCFHIET AHFEQNTLER NFERINTVQY GTSDNKKDNT LQCGMEVNSS ILSGCASNHP KNSAQNLTKD STLKHEGFYS ENLTESRKFL KSREKQSSLT EIKGSVYETT YSPPECPFCG KIEEHSEDME THVKTKHANL LDIPLEDCDQ PLYDCPMCGL ICTNYHILQE HVDLHLEENS FQQGMDRVQC SGDLQLAHQL QQEEDRKRRS EESRQEIEEF QKLQRQYGLD NSGGYKQQQL RNMEIEVNRG RMPPSEFHRR KADMMESLAL GFDDGKTKTS GIIEALHRYY QNAATDVRRV WLSSVVDHFH SSLGDKGWGC GYRNFQMLLS SLLQNDAYND CLKGMLIPCI PKIQSMIEDA WKEGFDPQGA SQLNNRLQGT KAWIGACEVY ILLTSLRVKC HIVDFHKSTG PLGTHPRLFE WILNYYSSEG EGSPKVVCTS KPPIYLQHQG HSRTVIGIEE KKNRTLCLLI LDPGCPSREM QKLLKQDIEA SSLKQLRKSM GNLKHKQYQI LAVEGALSLE EKLARRQASQ VFTAEKIP
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