Endothelial cell-selective adhesion molecule (ESAM)

About Endothelial cell-selective adhesion molecule

Endothelial cell-selective adhesion molecule (ESAM) is a protein from Homo sapiens identified by UniProt accession Q96AP7, 390 residues long. MolForge cross-references it against 0 known binders and 169 disease associations.

Target properties

Protein name	Endothelial cell-selective adhesion molecule
UniProt accession	Q96AP7
Gene	ESAM
Organism	Homo sapiens
Length	390 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (169)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity · score 0.69
breast adenocarcinoma · score 0.18
head and neck squamous cell carcinoma · score 0.11
endothelial cell-selective adhesion molecule measurement · score 0.11
low grade glioma · score 0.10
blood protein measurement · score 0.09
acute myeloid leukemia · score 0.07
neoplasm · score 0.05
schizophrenia · score 0.05
attention deficit hyperactivity disorder · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96AP7-F1	alphafold	PREDICTED	77.55	—

Amino-acid sequence (390 residues)

MISLPGPLVT NLLRFLFLGL SALAPPSRAQ LQLHLPANRL QAVEGGEVVL PAWYTLHGEV SSSQPWEVPF VMWFFKQKEK EDQVLSYING VTTSKPGVSL VYSMPSRNLS LRLEGLQEKD SGPYSCSVNV QDKQGKSRGH SIKTLELNVL VPPAPPSCRL QGVPHVGANV TLSCQSPRSK PAVQYQWDRQ LPSFQTFFAP ALDVIRGSLS LTNLSSSMAG VYVCKAHNEV GTAQCNVTLE VSTGPGAAVV AGAVVGTLVG LGLLAGLVLL YHRRGKALEE PANDIKEDAI APRTLPWPKS SDTISKNGTL SSVTSARALR PPHGPPRPGA LTPTPSLSSQ ALPSPRLPTT DGAHPQPISP IPGGVSSSGL SRMGAVPVMV PAQSQAGSLV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards