About Vacuolar protein sorting-associated protein 33A
Vacuolar protein sorting-associated protein 33A (VPS33A) is a protein
from Homo sapiens identified by UniProt accession
Q96AX1, 596 residues long.
MolForge cross-references it against 0 known binders and
259 disease associations.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 33A |
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| UniProt accession | Q96AX1 |
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| Gene | VPS33A |
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| Organism | Homo sapiens |
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| Length | 596 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (259)
Diseases linked to this target (Open Targets).
- mucopolysaccharidosis-plus syndrome · score 0.70
- neurodegenerative disease · score 0.50
- COVID-19 · score 0.37
- C-reactive protein measurement · score 0.16
- self reported educational attainment · score 0.14
- X-linked intellectual disability-retinitis pigmentosa syndrome · score 0.07
- Griscelli syndrome type 3 · score 0.06
- high density lipoprotein cholesterol measurement · score 0.06
- body mass index · score 0.06
- Tietz syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AX1-F1 | alphafold | PREDICTED | 93.86 | — |
Amino-acid sequence (596 residues)
MAAHLSYGRV NLNVLREAVR RELREFLDKC AGSKAIVWDE YLTGPFGLIA QYSLLKEHEV EKMFTLKGNR LPAADVKNII FFVRPRLELM DIIAENVLSE DRRGPTRDFH ILFVPRRSLL CEQRLKDLGV LGSFIHREEY SLDLIPFDGD LLSMESEGAF KECYLEGDQT SLYHAAKGLM TLQALYGTIP QIFGKGECAR QVANMMIRMK REFTGSQNSI FPVFDNLLLL DRNVDLLTPL ATQLTYEGLI DEIYGIQNSY VKLPPEKFAP KKQGDGGKDL PTEAKKLQLN SAEELYAEIR DKNFNAVGSV LSKKAKIISA AFEERHNAKT VGEIKQFVSQ LPHMQAARGS LANHTSIAEL IKDVTTSEDF FDKLTVEQEF MSGIDTDKVN NYIEDCIAQK HSLIKVLRLV CLQSVCNSGL KQKVLDYYKR EILQTYGYEH ILTLHNLEKA GLLKPQTGGR NNYPTIRKTL RLWMDDVNEQ NPTDISYVYS GYAPLSVRLA QLLSRPGWRS IEEVLRILPG PHFEERQPLP TGLQKKRQPG ENRVTLIFFL GGVTFAEIAA LRFLSQLEDG GTEYVIATTK LMNGTSWIEA LMEKPF
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