About Structure-specific endonuclease subunit EME1
Structure-specific endonuclease subunit EME1 (EME1) is a protein
from Homo sapiens identified by UniProt accession
Q96AY2, 570 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | Structure-specific endonuclease subunit EME1 |
|---|
| UniProt accession | Q96AY2 |
|---|
| Gene | EME1 |
|---|
| Organism | Homo sapiens |
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| Length | 570 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (91)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- breast adenocarcinoma · score 0.25
- clear cell renal carcinoma · score 0.10
- primary familial polycythemia due to EPO receptor mutation · score 0.08
- hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.07
- Blackfan-Diamond anemia · score 0.07
- erythrocytosis, familial, 3 · score 0.06
- erythrocytosis, familial, 6 · score 0.06
- hepatocellular carcinoma · score 0.06
- Pyruvate kinase hyperactivity · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AY2-F1 | alphafold | PREDICTED | 67.50 | — |
Amino-acid sequence (570 residues)
MALKKSSPSL DSGDSDSEEL PTFAFLKKEP SSTKRRQPER EEKIVVVDIS DCEASCPPAP ELFSPPVPEI AETVTQTQPV RLLSSESEDE EEFIPLAQRL TCKFLTHKQL SPEDSSSPVK SVLDHQNNEG ASCDWKKPFP KIPEVPLHDT PERSAADNKD LILDPCCQLP AYLSTCPGQS SSLAVTKTNS DILPPQKKTK PSQKVQGRGS HGCRQQRQAR QKESTLRRQE RKNAALVTRM KAQRPEECLK HIIVVLDPVL LQMEGGGQLL GALQTMECRC VIEAQAVPCS VTWRRRAGPS EDREDWVEEP TVLVLLRAEA FVSMIDNGKQ GSLDSTMKGK ETLQGFVTDI TAKTAGKALS LVIVDQEKCF SAQNPPRRGK QGANKQTKKQ QQRQPEASIG SMVSRVDAEE ALVDLQLHTE AQAQIVQSWK ELADFTCAFT KAVAEAPFKK LRDETTFSFC LESDWAGGVK VDLAGRGLAL VWRRQIQQLN RVSLEMASAV VNAYPSPQLL VQAYQQCFSD KERQNLLADI QVRRGEGVTS TSRRIGPELS RRIYLQMTTL QPHLSLDSAD
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