About Peptidyl-prolyl cis-trans isomerase FKBP10
Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) is a protein
from Homo sapiens identified by UniProt accession
Q96AY3, 582 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | Peptidyl-prolyl cis-trans isomerase FKBP10 |
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| UniProt accession | Q96AY3 |
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| Gene | FKBP10 |
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| Organism | Homo sapiens |
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| Length | 582 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (133)
Diseases linked to this target (Open Targets).
- Bruck syndrome · score 0.72
- osteogenesis imperfecta · score 0.64
- osteogenesis imperfecta type 3 · score 0.46
- Skeletal dysplasia · score 0.46
- genetic disorder · score 0.41
- arthrogryposis-like syndrome · score 0.37
- osteogenesis imperfecta type 4 · score 0.37
- Abnormality of the skeletal system · score 0.34
- Recurrent fractures · score 0.34
- Kyphosis · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AY3-F1 | alphafold | PREDICTED | 88.80 | — |
Amino-acid sequence (582 residues)
MFPAGPPSHS LLRLPLLQLL LLVVQAVGRG LGRASPAGGP LEDVVIERYH IPRACPREVQ MGDFVRYHYN GTFEDGKKFD SSYDRNTLVA IVVGVGRLIT GMDRGLMGMC VNERRRLIVP PHLGYGSIGL AGLIPPDATL YFDVVLLDVW NKEDTVQVST LLRPPHCPRM VQDGDFVRYH YNGTLLDGTS FDTSYSKGGT YDTYVGSGWL IKGMDQGLLG MCPGERRKII IPPFLAYGEK GYGTVIPPQA SLVFHVLLID VHNPKDAVQL ETLELPPGCV RRAGAGDFMR YHYNGSLMDG TLFDSSYSRN HTYNTYIGQG YIIPGMDQGL QGACMGERRR ITIPPHLAYG ENGTGDKIPG SAVLIFNVHV IDFHNPADVV EIRTLSRPSE TCNETTKLGD FVRYHYNCSL LDGTQLFTSH DYGAPQEATL GANKVIEGLD TGLQGMCVGE RRQLIVPPHL AHGESGARGV PGSAVLLFEV ELVSREDGLP TGYLFVWHKD PPANLFEDMD LNKDGEVPPE EFSTFIKAQV SEGKGRLMPG QDPEKTIGDM FQNQDRNQDG KITVDELKLK SDEDEERVHE EL
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