About Tetratricopeptide repeat protein 28
Tetratricopeptide repeat protein 28 (TTC28) is a protein
from Homo sapiens identified by UniProt accession
Q96AY4, 2481 residues long.
MolForge cross-references it against 0 known binders and
147 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 28 |
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| UniProt accession | Q96AY4 |
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| Gene | TTC28 |
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| Organism | Homo sapiens |
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| Length | 2481 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (147)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.41
- sex hormone-binding globulin measurement · score 0.39
- leukocyte count · score 0.37
- cup-to-disc ratio measurement · score 0.36
- hematocrit · score 0.34
- refractive error measurement · score 0.34
- chronotype measurement · score 0.29
- body height · score 0.28
- pulse pressure measurement · score 0.27
- prostate carcinoma · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96AY4-F1 | alphafold | PREDICTED | 68.44 | — |
Amino-acid sequence (2481 residues)
MEQSPPPAPE PTQGPTPARS RRRREPESPP ASAPIPLFGA DTIGQRSPDG PVLSKAEFVE KVRQSNQACH DGDFHTAIVL YNEALAVDPQ NCILYSNRSA AYMKIQQYDK ALDDAIKARL LNPKWPKAYF RQGVALQYLG RHADALAAFA SGLAQDPKSL QLLVGMVEAA MKSPMRDSLE PTYQQLQKMK LDKSPFVVVS VVGQELLTAG HHGASVVVLE AALKIGTCSL KLRGSVFSAL SSAYWSLGNT EKSTGYMQQD LDVAKTLGDQ TGECRAHGNL GSAFFSKGNY REALTNHRHQ LVLAMKLKDR EAASSALSSL GHVYTAIGDY PNALASHKQC VLLAKQSKDE LSEARELGNM GAVYIAMGDF ENAVQCHEQH LKIAKDLGNK REEARAYSNL GSAYHYRRNF DKAMSYHNYV LELAQELMEK AIEMRAYAGL GHAARCMQDL ERAKQYHEQQ LGIAEDLKDR AAEGRASSNL GIIHQMKGDY DTALKLHKTH LCIAQELSDY AAQGRAYGNM GNAYNALGMY DQAVKYHRQE LQISMEVNDR ASQASTHGNL AVAYQALGAH DRALQHYQNH LNIARELRDI QSEARALSNL GNFHCSRGEY VQAAPYYEQY LRLAPDLQDM EGEGKVCHNL GYAHYCLGNY QEAVKYYEQD LALAKDLHDK LSQAKAYCNL GLAFKALLNF SKAEECQKYL LSLAQSLNNS QAKFRALGNL GDIFICKKDI NGAIKFYEQQ LGLAHQVKDR RLEASAYAAL GTAYRMIQKY DKALGYHTQE LEVYQELSDL PGECRAHGHL AAVYMALGKY TMAFKCYEEQ LDLGQKLKDP SLEAQVYGNM GITKMNMNVM EEAIGYFEQQ LAMLQQLSGN ESVLDRGRAY GNLGDCYEAL GDYEEAIKYY EQYLSVAQSL NRMQDQAKAY RGLGNGHRAM GSLQQALVCF EKRLVVAHEL GEAFNKAQAY GELGSLHSQL GNYEQAISCL ERQLNIARDM KDRALESDAA CGLGGVYQQM GEYDTALQYH QLDLQIAEET NNPTCQGRAY GNLGLTYESL GTFERAVVYQ EQHLSIAAQM NDLAAKTVSY SSLGRTHHAL QNYSQAVMYL QEGLRLAEQL GRREDEAKIR HGLGLSLWAS GNLEEAQHQL YRASALFETI RHEAQLSTDY KLSLFDLQTS SYQALQRVLV SLGHHDEALA VAERGRTRAF ADLLVERQTG QQDSDPYSPV TIDQILEMVN GQRGLVLYYS LAAGYLYSWL LAPGAGIVKF HEHYLGENTV ENSSDFQASS SVTLPTATGS ALEQHIASVR EALGVESHYS RACASSETES EAGDIMDQQF EEMNNKLNSV TDPTGFLRMV RRNNLFNRSC QSMTSLFSNT VSPTQDGTSS LPRRQSSFAK PPLRALYDLL IAPMEGGLMH SSGPVGRHRQ LILVLEGELY LIPFALLKGS SSNEYLYERF GLLAVPSIRS LSVQSKSHLR KNPPTYSSST SMAAVIGNPK LPSAVMDRWL WGPMPSAEEE AYMVSELLGC QPLVGSVATK ERVMSALTQA ECVHFATHIS WKLSALVLTP SMDGNPASSK SSFGHPYTIP ESLRVQDDAS DGESISDCPP LQELLLTAAD VLDLQLPVKL VVLGSSQESN SKVTADGVIA LTRAFLAAGA QCVLVSLWPV PVAASKMFIH AFYSSLLNGL KASAALGEAM KVVQSSKAFS HPSNWAGFML IGSDVKLNSP SSLIGQALTE ILQHPERARD ALRVLLHLVE KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG WQALLTAVGF RLDPPTSGLP AAVFFPTSDP GDRLQQCSST LQSLLGLPNP ALQALCKLIT ASETGEQLIS RAVKNMVGML HQVLVQLQAG EKEQDLASAP IQVSISVQLW RLPGCHEFLA ALGFDLCEVG QEEVILKTGK QANRRTVHFA LQSLLSLFDS TELPKRLSLD SSSSLESLAS AQSVSNALPL GYQQPPFSPT GADSIASDAI SVYSLSSIAS SMSFVSKPEG GSEGGGPGGR QDHDRSKNAY LQRSTLPRSQ LPPQTRPAGN KDEEEYEGFS IISNEPLATY QENRNTCFSP DHKQPQPGTA GGMRVSVSSK GSISTPNSPV KMTLIPSPNS PFQKVGKLAS SDTGESDQSS TETDSTVKSQ EESNPKLDPQ ELAQKILEET QSHLIAVERL QRSGGQVSKS NNPEDGVQAP SSTAVFRASE TSAFSRPVLS HQKSQPSPVT VKPKPPARSS SLPKVSSGYS SPTTSEMSIK DSPSQHSGRP SPGCDSQTSQ LDQPLFKLKY PSSPYSAHIS KSPRNMSPSS GHQSPAGSAP SPALSYSSAG SARSSPADAP DIDKLKMAAI DEKVQAVHNL KMFWQSTPQH STGPMKIFRG APGTMTSKRD VLSLLNLSPR HNKKEEGVDK LELKELSLQQ HDGAPPKAPP NGHWRTETTS LGSLPLPAGP PATAPARPLR LPSGNGYKFL SPGRFFPSSK C
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