About Dapper homolog 3
Dapper homolog 3 (DACT3) is a protein
from Homo sapiens identified by UniProt accession
Q96B18, 629 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Dapper homolog 3 |
|---|
| UniProt accession | Q96B18 |
|---|
| Gene | DACT3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 629 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- Intellectual disability · score 0.12
- hepatocellular carcinoma · score 0.07
- MODY · score 0.05
- diabetes mellitus, permanent neonatal 4 · score 0.05
- neoplasm · score 0.05
- permanent neonatal diabetes mellitus 1 · score 0.05
- ulcerative colitis · score 0.04
- acute myeloid leukemia · score 0.04
- congenital lethal erythroderma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96B18-F1 | alphafold | PREDICTED | 52.54 | — |
Amino-acid sequence (629 residues)
MIRAFSFPVS PERGRLRGWL EGSLAGLCEL HWLRERQEYR VQQALRLAQP GMGGAEAEDE EDADEDEDAA AARRAAAALE EQLEALPGLV WDLGQQLGDL SLESGGLEQE SGRSSGFYED PSSTGGPDSP PSTFCGDSGF SGSSSYGRLG PSEPRGIYAS ERPKSLGDAS PSAPEVVGAR AAVPRSFSAP YPTAGGSAGP EACSSAERRA RAGPFLTPSP LHAVAMRSPR PCGRPPTDSP DAGGAGRPLD GYISALLRRR RRRGAGQPRT SPGGADGGPR RQNSVRQRPP DASPSPGSAR PAREPSLERV GGHPTSPAAL SRAWASSWES EAAPEPAAPP AAPSPPDSPA EGRLVKAQYI PGAQAATRGL PGRAARRKPP PLTRGRSVEQ SPPRERPRAA GRRGRMAEAS GRRGSPRARK ASRSQSETSL LGRASAVPSG PPKYPTAERE EPRPPRPRRG PAPTLAAQAA GSCRRWRSTA EIDAADGRRV RPRAPAARVP GPGPSPSAPQ RRLLYGCAGS DSECSAGRLG PLGRRGPAGG VGGGYGESES SASEGESPAF SSASSDSDGS GGLVWPQQLV AATAASGGGA GAGAPAGPAK VFVKIKASHA LKKKILRFRS GSLKVMTTV
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