Exosome complex component RRP43 (EXOSC8)

About Exosome complex component RRP43

Exosome complex component RRP43 (EXOSC8) is a protein from Homo sapiens identified by UniProt accession Q96B26, 276 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	Exosome complex component RRP43
UniProt accession	Q96B26
Gene	EXOSC8
Organism	Homo sapiens
Length	276 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

pontocerebellar hypoplasia type 1 · score 0.57
neurodegenerative disease · score 0.52
spastic ataxia · score 0.34
distal hereditary motor neuropathy · score 0.18
lysosomal storage disease · score 0.14
breast adenocarcinoma · score 0.10
hyperinsulinism due to INSR deficiency · score 0.06
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
hemoglobin D disease · score 0.05
delta-beta-thalassemia · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96B26-F1	alphafold	PREDICTED	85.86	—

Amino-acid sequence (276 residues)

MAAGFKTVEP LEYYRRFLKE NCRPDGRELG EFRTTTVNIG SISTADGSAL VKLGNTTVIC GVKAEFAAPS TDAPDKGYVV PNVDLPPLCS SRFRSGPPGE EAQVASQFIA DVIENSQIIQ KEDLCISPGK LVWVLYCDLI CLDYDGNILD ACTFALLAAL KNVQLPEVTI NEETALAEVN LKKKSYLNIR THPVATSFAV FDDTLLIVDP TGEEEHLATG TLTIVMDEEG KLCCLHKPGG SGLTGAKLQD CMSRAVTRHK EVKKLMDEVI KSMKPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards