Proline-rich AKT1 substrate 1 (AKT1S1)

About Proline-rich AKT1 substrate 1

Proline-rich AKT1 substrate 1 (AKT1S1) is a protein from Homo sapiens identified by UniProt accession Q96B36, 256 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.

Target properties

Protein name	Proline-rich AKT1 substrate 1
UniProt accession	Q96B36
Gene	AKT1S1
Organism	Homo sapiens
Length	256 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (101)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.09
neoplasm · score 0.08
head and neck squamous cell carcinoma · score 0.08
nonpapillary renal cell carcinoma · score 0.08
cancer · score 0.04
kidney neoplasm · score 0.03
transient ischemic attack · score 0.03
lean body mass · score 0.02
fat body mass · score 0.02
atherosclerosis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96B36-F1	alphafold	PREDICTED	66.92	—

Amino-acid sequence (256 residues)

MASGRPEELW EAVVGAAERF RARTGTELVL LTAAPPPPPR PGPCAYAAHG RGALAEAARR CLHDIALAHR AATAARPPAP PPAPQPPSPT PSPPRPTLAR EDNEEDEDEP TETETSGEQL GISDNGGLFV MDEDATLQDL PPFCESDPES TDDGSLSEET PAGPPTCSVP PASALPTQQY AKSLPVSVPV WGFKEKRTEA RSSDEENGPP SSPDLDRIAA SMRALVLREA EDTQVFGDLP RPRLNTSDFQ KLKRKY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards