Arrestin domain-containing protein 3 (ARRDC3)

About Arrestin domain-containing protein 3

Arrestin domain-containing protein 3 (ARRDC3) is a protein from Homo sapiens identified by UniProt accession Q96B67, 414 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.

Target properties

Protein name	Arrestin domain-containing protein 3
UniProt accession	Q96B67
Gene	ARRDC3
Organism	Homo sapiens
Length	414 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (111)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.42
mean corpuscular hemoglobin concentration · score 0.36
breast carcinoma · score 0.36
neurodegenerative disease · score 0.36
platelet component distribution width · score 0.35
hippocampal tail volume · score 0.30
mathematical ability · score 0.29
mean corpuscular hemoglobin · score 0.29
creatinine measurement · score 0.28
neuroimaging measurement · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96B67-F1	alphafold	PREDICTED	82.20	—

Amino-acid sequence (414 residues)

MVLGKVKSLT ISFDCLNDSN VPVYSSGDTV SGRVNLEVTG EIRVKSLKIH ARGHAKVRWT ESRNAGSNTA YTQNYTEEVE YFNHKDILIG HERDDDNSEE GFHTIHSGRH EYAFSFELPQ TPLATSFEGR HGSVRYWVKA ELHRPWLLPV KLKKEFTVFE HIDINTPSLL SPQAGTKEKT LCCWFCTSGP ISLSAKIERK GYTPGESIQI FAEIENCSSR MVVPKAAIYQ TQAFYAKGKM KEVKQLVANL RGESLSSGKT ETWNGKLLKI PPVSPSILDC SIIRVEYSLM VYVDIPGAMD LFLNLPLVIG TIPLHPFGSR TSSVSSQCSM NMNWLSLSLP ERPEAPPSYA EVVTEEQRRN NLAPVSACDD FERALQGPLF AYIQEFRFLP PPLYSEIDPN PDQSADDRPS CPSR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards