About Transmembrane protein 186
Transmembrane protein 186 (TMEM186) is a protein
from Homo sapiens identified by UniProt accession
Q96B77, 213 residues long.
MolForge cross-references it against 0 known binders and
9 disease associations.
Target properties
| Protein name | Transmembrane protein 186 |
|---|
| UniProt accession | Q96B77 |
|---|
| Gene | TMEM186 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 213 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (9)
Diseases linked to this target (Open Targets).
- sphingomyelin measurement · score 0.13
- diffuse plaque measurement · score 0.05
- response to opioid · score 0.03
- insulin like growth factor measurement · score 0.03
- forced expiratory volume · score 0.03
- platelet count · score 0.02
- systemic juvenile idiopathic arthritis · score 0.01
- cancer · score 0.00
- acute myeloid leukemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96B77-F1 | alphafold | PREDICTED | 60.48 | — |
Amino-acid sequence (213 residues)
MAALLRAVRR FRGKAVWERP LHGLWCCSGQ EDPKRWVGSS SPISKEKLPN AETEKFWMFY RFDAIRTFGF LSRLKLAQTA LTVVALPPGY YLYSQGLLTL NTVCLMSGIS GFALTMLCWM SYFLRRLVGI LYLNESGTML RVAHLNFWGW RQDTYCPMAD VIPLTETKDR PQEMFVRIQR YSGKQTFYVT LRYGRILDRE RFTQVFGVHQ MLK
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