About SH3 domain-containing kinase-binding protein 1
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) is a protein
from Homo sapiens identified by UniProt accession
Q96B97, 665 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | SH3 domain-containing kinase-binding protein 1 |
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| UniProt accession | Q96B97 |
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| Gene | SH3KBP1 |
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| Organism | Homo sapiens |
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| Length | 665 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (76)
Diseases linked to this target (Open Targets).
- X-linked agammaglobulinemia · score 0.46
- listeriosis · score 0.46
- lung adenocarcinoma · score 0.27
- thyroid gland adenocarcinoma · score 0.26
- breast adenocarcinoma · score 0.25
- cutaneous melanoma · score 0.23
- endometrial cancer · score 0.23
- neurodegenerative disease · score 0.23
- head and neck squamous cell carcinoma · score 0.20
- low grade glioma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96B97-F1 | alphafold | PREDICTED | 62.17 | — |
Amino-acid sequence (665 residues)
MVEAIVEFDY QAQHDDELTI SVGEIITNIR KEDGGWWEGQ INGRRGLFPD NFVREIKKEM KKDPLTNKAP EKPLHEVPSG NSLLSSETIL RTNKRGERRR RRCQVAFSYL PQNDDELELK VGDIIEVVGE VEEGWWEGVL NGKTGMFPSN FIKELSGESD ELGISQDEQL SKSSLRETTG SESDGGDSSS TKSEGANGTV ATAAIQPKKV KGVGFGDIFK DKPIKLRPRS IEVENDFLPV EKTIGKKLPA TTATPDSSKT EMDSRTKSKD YCKVIFPYEA QNDDELTIKE GDIVTLINKD CIDVGWWEGE LNGRRGVFPD NFVKLLPPDF EKEGNRPKKP PPPSAPVIKQ GAGTTERKHE IKKIPPERPE MLPNRTEEKE RPEREPKLDL QKPSVPAIPP KKPRPPKTNS LSRPGALPPR RPERPVGPLT HTRGDSPKID LAGSSLSGIL DKDLSDRSND IDLEGFDSVV SSTEKLSHPT TSRPKATGRR PPSQSLTSSS LSSPDIFDSP SPEEDKEEHI SLAHRGVDAS KKTSKTVTIS QVSDNKASLP PKPGTMAAGG GGPAPLSSAA PSPLSSSLGT AGHRANSPSL FGTEGKPKME PAASSQAAVE ELRTQVRELR SIIETMKDQQ KREIKQLLSE LDEEKKIRLR LQMEVNDIKK ALQSK
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