About Cyclic AMP-responsive element-binding protein 3-like protein 1
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) is a protein
from Homo sapiens identified by UniProt accession
Q96BA8, 519 residues long.
MolForge cross-references it against 0 known binders and
297 disease associations.
Target properties
| Protein name | Cyclic AMP-responsive element-binding protein 3-like protein 1 |
|---|
| UniProt accession | Q96BA8 |
|---|
| Gene | CREB3L1 |
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| Organism | Homo sapiens |
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| Length | 519 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (297)
Diseases linked to this target (Open Targets).
- osteogenesis imperfecta · score 0.52
- osteogenesis imperfecta type 3 · score 0.37
- synovial sarcoma · score 0.37
- undifferentiated pleomorphic sarcoma · score 0.37
- well-differentiated liposarcoma · score 0.37
- leiomyosarcoma · score 0.37
- malignant peripheral nerve sheath tumor · score 0.37
- breast ductal adenocarcinoma · score 0.37
- lipoma · score 0.37
- neurofibroma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96BA8-F1 | alphafold | PREDICTED | 55.13 | — |
Amino-acid sequence (519 residues)
MDAVLEPFPA DRLFPGSSFL DLGDLNESDF LNNAHFPEHL DHFTENMEDF SNDLFSSFFD DPVLDEKSPL LDMELDSPTP GIQAEHSYSL SGDSAPQSPL VPIKMEDTTQ DAEHGAWALG HKLCSIMVKQ EQSPELPVDP LAAPSAMAAA AAMATTPLLG LSPLSRLPIP HQAPGEMTQL PVIKAEPLEV NQFLKVTPED LVQMPPTPPS SHGSDSDGSQ SPRSLPPSSP VRPMARSSTA ISTSPLLTAP HKLQGTSGPL LLTEEEKRTL IAEGYPIPTK LPLTKAEEKA LKRVRRKIKN KISAQESRRK KKEYVECLEK KVETFTSENN ELWKKVETLE NANRTLLQQL QKLQTLVTNK ISRPYKMAAT QTGTCLMVAA LCFVLVLGSL VPCLPEFSSG SQTVKEDPLA ADGVYTASQM PSRSLLFYDD GAGLWEDGRS TLLPMEPPDG WEINPGGPAE QRPRDHLQHD HLDSTHETTK YLSEAWPKDG GNGTSPDFSH SKEWFHDRDL GPNTTIKLS
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