About Solute carrier organic anion transporter family member 4A1
Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is a protein
from Homo sapiens identified by UniProt accession
Q96BD0, 722 residues long.
MolForge cross-references it against 0 known binders and
98 disease associations.
Target properties
| Protein name | Solute carrier organic anion transporter family member 4A1 |
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| UniProt accession | Q96BD0 |
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| Gene | SLCO4A1 |
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| Organism | Homo sapiens |
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| Length | 722 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (98)
Diseases linked to this target (Open Targets).
- age at menopause · score 0.39
- type 2 diabetes mellitus · score 0.34
- menopause · score 0.27
- hemoglobin A1 measurement · score 0.25
- brain volume measurement · score 0.23
- neuroimaging measurement · score 0.22
- cutaneous melanoma · score 0.22
- diet measurement · score 0.19
- brain measurement · score 0.16
- white matter integrity · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96BD0-F1 | alphafold | PREDICTED | 77.88 | — |
Amino-acid sequence (722 residues)
MPLHQLGDKP LTFPSPNSAM ENGLDHTPPS RRASPGTPLS PGSLRSAAHS PLDTSKQPLC QLWAEKHGAR GTHEVRYVSA GQSVACGWWA FAPPCLQVLN TPKGILFFLC AAAFLQGMTV NGFINTVITS LERRYDLHSY QSGLIASSYD IAACLCLTFV SYFGGSGHKP RWLGWGVLLM GTGSLVFALP HFTAGRYEVE LDAGVRTCPA NPGAVCADST SGLSRYQLVF MLGQFLHGVG ATPLYTLGVT YLDENVKSSC SPVYIAIFYT AAILGPAAGY LIGGALLNIY TEMGRRTELT TESPLWVGAW WVGFLGSGAA AFFTAVPILG YPRQLPGSQR YAVMRAAEMH QLKDSSRGEA SNPDFGKTIR DLPLSIWLLL KNPTFILLCL AGATEATLIT GMSTFSPKFL ESQFSLSASE AATLFGYLVV PAGGGGTFLG GFFVNKLRLR GSAVIKFCLF CTVVSLLGIL VFSLHCPSVP MAGVTASYGG SLLPEGHLNL TAPCNAACSC QPEHYSPVCG SDGLMYFSLC HAGCPAATET NVDGQKVYRD CSCIPQNLSS GFGHATAGKC TSTCQRKPLL LVFIFVVIFF TFLSSIPALT ATLRCVRDPQ RSFALGIQWI VVRILGGIPG PIAFGWVIDK ACLLWQDQCG QQGSCLVYQN SAMSRYILIM GLLYKVLGVL FFAIACFLYK PLSESSDGLE TCLPSQSSAP DSATDSQLQS SV
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