About PHD finger protein 21A
PHD finger protein 21A (PHF21A) is a protein
from Homo sapiens identified by UniProt accession
Q96BD5, 680 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | PHD finger protein 21A |
|---|
| UniProt accession | Q96BD5 |
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| Gene | PHF21A |
|---|
| Organism | Homo sapiens |
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| Length | 680 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (66)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with macrocephaly and with or without seizures · score 0.67
- Potocki-Shaffer syndrome · score 0.61
- neurodegenerative disease · score 0.55
- genetic disorder · score 0.51
- Intellectual disability · score 0.49
- peeling skin syndrome · score 0.46
- complex neurodevelopmental disorder · score 0.37
- body height · score 0.28
- age at menarche · score 0.26
- self reported educational attainment · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96BD5-F1 | alphafold | PREDICTED | 58.07 | — |
Amino-acid sequence (680 residues)
MELQTLQEAL KVEIQVHQKL VAQMKQDPQN ADLKKQLHEL QAKITALSEK QKRVVEQLRK NLIVKQEQPD KFQIQPLPQS ENKLQTAQQQ PLQQLQQQQQ YHHHHAQQSA AASPNLTASQ KTVTTASMIT TKTLPLVLKA ATATMPASVV GQRPTIAMVT AINSQKAVLS TDVQNTPVNL QTSSKVTGPG AEAVQIVAKN TVTLVQATPP QPIKVPQFIP PPRLTPRPNF LPQVRPKPVA QNNIPIAPAP PPMLAAPQLI QRPVMLTKFT PTTLPTSQNS IHPVRVVNGQ TATIAKTFPM AQLTSIVIAT PGTRLAGPQT VQLSKPSLEK QTVKSHTETD EKQTESRTIT PPAAPKPKRE ENPQKLAFMV SLGLVTHDHL EEIQSKRQER KRRTTANPVY SGAVFEPERK KSAVTYLNST MHPGTRKRGR PPKYNAVLGF GALTPTSPQS SHPDSPENEK TETTFTFPAP VQPVSLPSPT STDGDIHEDF CSVCRKSGQL LMCDTCSRVY HLDCLDPPLK TIPKGMWICP RCQDQMLKKE EAIPWPGTLA IVHSYIAYKA AKEEEKQKLL KWSSDLKQER EQLEQKVKQL SNSISKCMEM KNTILARQKE MHSSLEKVKQ LIRLIHGIDL SKPVDSEATV GAISNGPDCT PPANAATSTP APSPSSQSCT ANCNQGEETK
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