Nucleus accumbens-associated protein 2 (NACC2)

About Nucleus accumbens-associated protein 2

Nucleus accumbens-associated protein 2 (NACC2) is a protein from Homo sapiens identified by UniProt accession Q96BF6, 587 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Nucleus accumbens-associated protein 2
UniProt accession	Q96BF6
Gene	NACC2
Organism	Homo sapiens
Length	587 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

urate measurement · score 0.30
medulloblastoma · score 0.03
glioblastoma · score 0.03
large cell medulloblastoma · score 0.02
ovarian carcinoma · score 0.01
Alzheimer disease · score 0.01
tuberculosis · score 0.01
infect · score 0.01
infection · score 0.01
childhood leukemia · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96BF6-F1	alphafold	PREDICTED	60.71	—

Amino-acid sequence (587 residues)

MSQMLHIEIP NFGNTVLGCL NEQRLLGLYC DVSIVVKGQA FKAHRAVLAA SSLYFRDLFS GNSKSAFELP GSVPPACFQQ ILSFCYTGRL TMTASEQLVV MYTAGFLQIQ HIVERGTDLM FKVSSPHCDS QTAVIEDAGS EPQSPCNQLQ PAAAAAAPYV VSPSVPIPLL TRVKHEAMEL PPAGPGLAPK RPLETGPRDG VAVAAGAAVA AGTAPLKLPR VSYYGVPSLA TLIPGIQQMP YPQGERTSPG ASSLPTTDSP TSYHNEEDEE DDEAYDTMVE EQYGQMYIKA SGSYAVQEKP EPVPLESRSC VLIRRDLVAL PASLISQIGY RCHPKLYSEG DPGEKLELVA GSGVYITRGQ LMNCHLCAGV KHKVLLRRLL ATFFDRNTLA NSCGTGIRSS TSDPSRKPLD SRVLNAVKLY CQNFAPSFKE SEMNVIAADM CTNARRVRKR WLPKIKSMLP EGVEMYRTVM GSAAASVPLD PEFPPAAAQV FEQRIYAERR GDAATIVALR TDAVNVDLSA AANPAFDAGE EVDGAGSVIQ EVAAPEPLPA DGQSPPQPFE QGGGGPSRPQ TPAAAARRPE GTYAGTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards