About Gamma-secretase subunit APH-1A
Gamma-secretase subunit APH-1A (APH1A) is a protein
from Homo sapiens identified by UniProt accession
Q96BI3, 265 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Gamma-secretase subunit APH-1A |
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| UniProt accession | Q96BI3 |
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| Gene | APH1A |
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| Organism | Homo sapiens |
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| Length | 265 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.39
- Dementia · score 0.32
- Desmoid-type fibromatosis · score 0.29
- head and neck squamous cell carcinoma · score 0.28
- breast adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.21
- ovarian cancer · score 0.18
- cutaneous melanoma · score 0.14
- multiple myeloma · score 0.10
- breast cancer · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96BI3-F1 | alphafold | PREDICTED | 91.81 | — |
Amino-acid sequence (265 residues)
MGAAVFFGCT FVAFGPAFAL FLITVAGDPL RVIILVAGAF FWLVSLLLAS VVWFILVHVT DRSDARLQYG LLIFGAAVSV LLQEVFRFAY YKLLKKADEG LASLSEDGRS PISIRQMAYV SGLSFGIISG VFSVINILAD ALGPGVVGIH GDSPYYFLTS AFLTAAIILL HTFWGVVFFD ACERRRYWAL GLVVGSHLLT SGLTFLNPWY EASLLPIYAV TVSMGLWAFI TAGGSLRSIQ RSLLCRRQED SRVMVYSALR IPPED
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