About Ubiquitin thioesterase otulin
Ubiquitin thioesterase otulin (OTULIN) is a protein
from Homo sapiens identified by UniProt accession
Q96BN8, 352 residues long.
MolForge cross-references it against 0 known binders and
93 disease associations.
Target properties
| Protein name | Ubiquitin thioesterase otulin |
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| UniProt accession | Q96BN8 |
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| Gene | OTULIN |
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| Organism | Homo sapiens |
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| Length | 352 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (93)
Diseases linked to this target (Open Targets).
- infantile-onset periodic fever-panniculitis-dermatosis syndrome · score 0.79
- immunodeficiency 107, susceptibility to invasive staphylococcus aureus infection · score 0.63
- Eczematoid dermatitis · score 0.41
- allergic rhinitis · score 0.40
- asthma · score 0.37
- type 2 diabetes mellitus · score 0.31
- serum non-albumin protein measurement · score 0.28
- eosinophil count · score 0.27
- neurofibrillary tangles measurement · score 0.24
- HbA1c measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96BN8-F1 | alphafold | PREDICTED | 83.79 | — |
Amino-acid sequence (352 residues)
MSRGTMPQPE AWPGASCAET PAREAAATAR DGGKAAASGQ PRPEMQCPAE HEEDMYRAAD EIEKEKELLI HERGASEPRL SVAPEMDIMD YCKKEWRGNT QKATCMKMGY EEVSQKFTSI RRVRGDNYCA LRATLFQAMS QAVGLPPWLQ DPELMLLPEK LISKYNWIKQ WKLGLKFDGK NEDLVDKIKE SLTLLRKKWA GLAEMRTAEA RQIACDELFT NEAEEYSLYE AVKFLMLNRA IELYNDKEKG KEVPFFSVLL FARDTSNDPG QLLRNHLNQV GHTGGLEQVE MFLLAYAVRH TIQVYRLSKY NTEEFITVYP TDPPKDWPVV TLIAEDDRHY NIPVRVCEET SL
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