About Peptidylprolyl isomerase domain and WD repeat-containing protein 1
Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (PPWD1) is a protein
from Homo sapiens identified by UniProt accession
Q96BP3, 646 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 |
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| UniProt accession | Q96BP3 |
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| Gene | PPWD1 |
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| Organism | Homo sapiens |
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| Length | 646 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- reticulocyte count · score 0.21
- neuroimaging measurement · score 0.14
- brain volume measurement · score 0.14
- brain measurement · score 0.13
- feeling tense measurement · score 0.11
- reticulocyte measurement · score 0.10
- refractive error measurement · score 0.10
- thalamus volume · score 0.09
- DNA methylation · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96BP3-F1 | alphafold | PREDICTED | 85.88 | — |
Amino-acid sequence (646 residues)
MAAESGSDFQ QRRRRRRDPE EPEKTELSER ELAVAVAVSQ ENDEENEERW VGPLPVEATL AKKRKVLEFE RVYLDNLPSA SMYERSYMHR DVITHVVCTK TDFIITASHD GHVKFWKKIE EGIEFVKHFR SHLGVIESIA VSSEGALFCS VGDDKAMKVF DVVNFDMINM LKLGYFPGQC EWIYCPGDAI SSVAASEKST GKIFIYDGRG DNQPLHIFDK LHTSPLTQIR LNPVYKAVVS SDKSGMIEYW TGPPHEYKFP KNVNWEYKTD TDLYEFAKCK AYPTSVCFSP DGKKIATIGS DRKVRIFRFV TGKLMRVFDE SLSMFTELQQ MRQQLPDMEF GRRMAVEREL EKVDAVRLIN IVFDETGHFV LYGTMLGIKV INVETNRCVR ILGKQENIRV MQLALFQGIA KKHRAATTIE MKASENPVLQ NIQADPTIVC TSFKKNRFYM FTKREPEDTK SADSDRDVFN EKPSKEEVMA ATQAEGPKRV SDSAIIHTSM GDIHTKLFPV ECPKTVENFC VHSRNGYYNG HTFHRIIKGF MIQTGDPTGT GMGGESIWGG EFEDEFHSTL RHDRPYTLSM ANAGSNTNGS QFFITVVPTP WLDNKHTVFG RVTKGMEVVQ RISNVKVNPK TDKPYEDVSI INITVK
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